4 application of bone tissue engineering platforms to study mechanisms of bone metastasis
Towards topical antifibrotics in tissue engineering and repair
... in the Tissue Modulation Laboratory gave me strength to get this far i Table of contents Table of contents ii Summary v List of abbreviations vii List of tables ... crowdedness of property of macromolecules the is determined by approximation of solute content For the interior of cells, concentrations of macromolecules have been determined to be in a range from 50 to ... methodologies to accomplish these aims are briefly described 1.1 Background Fibrosis, a pathological accumulation of collagen in tissues, represents a major global disease burden In the field of tissue engineering, ...
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Synthesis and characterization of collagen terpolymer fibers for applications in tissue engineering
... conditions [13] to deliver the construct to the desired site and to direct new tissue formation into the scaffolds [14] Some of the successes of Tissue Engineering include: engineering of artificial ... the supply of donor organs and tissues available This severe organ shortage led to the inception of Tissue Engineering Tissue Engineering is about developing new approaches to encourage tissue growth ... design of biomaterials is important in the field of tissue engineering and regenerative medicine Since the development of tissue engineering scaffolds, there is a need for these constructs to function...
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Laser surface structuring of biocompatible polymers films for potential use in tissue engineering applications
... the degree of Doctor of Philosophy in the Department of Mechanical Engineering at the National University of Singapore under the supervision of Professor Teoh Swee Hin and Associate Professor Hong ... Then, there is the perennial deficiency of synthetic materials to provide the multifunctional requirement of organ The aim of tissue engineering is to restore tissue and organ functions with minimal ... techniques of the fabrication of PCL thin films through solvent-cast and hot-roll milling can allow the thickness of the film to be drawn to a minimum of 10 μm thick One of the objectives is to be...
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biopolymer methods in tissue engineering
... 1.2 Tissue- Engineering Scaffolds The main goal of tissue engineering is to produce new tissue where it is needed Therefore, knowledge of the structure and functional limits of the regenerated tissue ... Goldberg, V., and Johnstone, B (1999) Engineering of osteochondral tissue with bone marrow mesenchymal progenitor cells in a derivatized hyaluronan-gelatin composite sponge Tissue Engineering 5, 545–554 ... the density of the FMB by layering an aliquot of it onto a sucrose solution of known density After centrifugation, one can observe that the FMB settles to the bottom or remains on top of the sucrose...
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Báo cáo hóa học: " Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery" doc
... valuable option [13] However, due to the complexity of the setup, such technique is only suitable for short term study (i.e., 2-4 h) The tool of Page of delivering DCU to a chronic model for preclinical ... MiniFlex II desktop X-ray powder diffractometer Radiation of Cu Ka at 30 kV-15 mA was used with a 2θ increment rate of 3°/min The scans ran over a range of 2-40° 2θ with a step size of 0.02° and ... in-house and was used to calculate the drug absorbed to further assess the amount of drug absorbed as a function of time [25,26] The utilization of the W-N equation allows us to obtain all the drug...
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báo cáo khoa học:" Gene-enhanced tissue engineering for dental hard tissue regeneration: (2) dentin-pulp and periodontal regeneration" pptx
... comparative analysis of radiography, microcomputed tomography, and histology for bone tissue engineering Tissue Eng 2005, 11:1356-1367 Weinberg MA, Brai M: Laboratory animal models in periodontology J Clin ... applicability of any dental hard tissue regenerative protocol could include the regeneration of an entire missing tooth or the regeneration of specific components of an otherwise viable tooth (e.g ... be triggered to differentiate into odontoblastic-like cells under the influence of specific growth factors [6,7] Of the numerous growth factors normally expressed during primary odontogenesis (for...
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báo cáo khoa học:" Prospects of micromass culture technology in tissue engineering" pot
... micro -tissue had a characteristic extracellular space that was similar to the natural matrix of hyaline cartilage Osteoblasts were also able to build up a micro -tissue similar to that of bone ... by the density of the condensation [19] Technical aspects of the micromass technology In the context of tissue engineering, ex vivo tissue generation may be optimised by the use of cell re-aggregation ... (sizes of the culture plate, movement in a bioreactor, coating of culture walls) are all crucial to the process Roller tube culture system have been shown to be suitable for cultivation of tissue...
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Applications of prolyl hydroxylase inhibitors in tissue engineering and regenerative medicine
... Roles of PHIs in Bone Tissue Engineering and Regeneration 64 4.1 Introduction 65 4.2 Bone development and regeneration 65 4.2.1 Mechanisms of bone formation 65 4.2.2 Bone ... suppress the production of collagen, an important component of bone Therefore, PHIs’ effects on bone are complex To explore PHIs’ effects on bone, we performed a preliminary study to investigate PHIs’ ... 3.5 (a) Cytotoxicity was monitored by measuring the leakage of G6PD from compromised cells, using Invitrogen’s Vybrant cytotoxicity assay Results show that PDCA-Gelfoam has low cytotoxicity (
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mobile mini robots for engineering, Vol.6, No.1 Published in Australia© 2002 pdf
... Design of a user interface for remote control Transmission of camera data to the remote operator Identification of problems due to limited sensor characterisation of the environment Combination of ... appointed to the editorial board of the journals Space Technologie and Control Engineering Practice Prof Dr-Ing Hubert Roth is Chair for Control Systems Engineering at the University of Siegen ... with autonomous obstacle avoidance Selection of an appropriate sensor system Identification of passive objects by sensors Path planning to a target Autonomous docking at the target Autonomous...
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Báo cáo khoa học: "Simultaneous in-field boost for patients with 1 to 4 brain metastasis/es treated with volumetric modulated arc therapy: a prospective study on quality-of-life" potx
... 21 72.5 From March 2010 to December 2010, 29 patients with previously untreated brain metastasis were included into an institutional prospective protocol of WBRT with SIB to single or multiple ... high level of functioning, respectively Conversely, a high score for a symptom scale represents a high level of symptomatology The self-administered QoL questionnaire BN20 consists of multi-items ... these good- to intermediate-prognosis patients There were several limitations of our study First, the small sample size of 29 patients limited the statistical power to assess fully the QoL of BM patients...
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Báo cáo y học: "Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation" pdf
... differentiation of stem/progenitor cells, it is necessary to down-regulate production of Sox2 (important for branching of airways) Page of [85] and consider the application of tissue- specific growth factors ... inflammatory cells of the airways also release inflammatory mediators such as transforming growth factor (TGF)-b1 and tumor necrosis factor-a that influence the production of matrix molecules [49] Tissue ... been developed For example, the development of a tissueengineered model of human bronchiole consisting of primary cells and designed to study mechanisms of airway remodeling and lung inflammation...
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Báo cáo y học: "Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue" docx
... mimics infection of lymphatic tissues, one of the major sites of viral Page of 13 replication in vivo [28] To study the effect of the S52A change in Vpu on HIV-1 replication and cytopathicity, we ... tonsillectomy was received within hours of excision The tonsils were washed thoroughly with medium containing antibiotics and sectioned into 2- to 3-mm3 blocks These tissue blocks were placed on top of ... by the usage of the CCR5 co-receptor Thus, it is also tempting to speculate that viral co-receptor tropism, i.e the usage of CCR5 for viral entry segregates with the ability of Vpu to efficiently...
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Vascularised bone tissue engineering endothelial progenitor cells and human mesenchymal stem cells coculture in 3d honeycomb scaffolds and the effect of bi rotational bioreactor and hypoxic microenvironment 1
... of the long bone and microstructure of vascularised bone tissue and the comparative porosity of compact bone and spongy bone Figure 2-2 A schematic of the hierarchical structure of bone from a ... sesamoid bones which are embedded within a tendon These bones are generally categorised into four groups – the long bones, short bones, flat bones and irregular bones (Clarke 2008) 2.2 Anatomy of Bone ... subnanostructure of collagen molecules to a nanostructure of cylindrically arranged microfibrils to lamellar layers forming the macrostructure of cortical bone Figure 2-3 Vascularised bone anatomy and...
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Applying side effects of anti fibrotic compounds to promote neovascularization for tissue engineering 1
... substances to promote angiogenesis by stabilization of the transcription factor HIF-1α and subsequent upregulation of relevant gene targets The use of this approach to improve vascularization of tissue ... Characterization of PHi Effects on Zebrafish Embryo Angiogenesis 68 3.4.3 PHi Dose Dependently Induced Ectopic SIVs in Zebrafish Embryos 72 3.5 Cytotoxicity of PHi 74 3.6 Inhibition of Collagen Biosynthesis ... viability and function of implanted tissue engineered constructs and biomaterials Slow neovascularization can compromise delivery of oxygen and nutrients to cells in the interior of a tissue construct;...
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Development of three dimensional fibrous structures via electrospinning for applications in scaffold based tissue engineering
... was proven to be more osteo-conductive as judged by proliferative capacity of bone marrow progenitor cells and their development into mature bone- like tissue v Functionalization of the PCL with ... Summary A vast body of literature shows that the electrospinning technique offers unique advantages in the production of tissue engineering scaffolds compared to other methods in terms of simplicity, ... tests were carried out to examine the strength and the effect of varying amounts of collagen towards the electrospun fibers Graphs A to C illustrate the effects of composition towards Young’s modulus,...
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Development of cell sheet constructs for layer by layer tissue engineering using the blood vessel as an experimental model 1
... activated factor 12, fXI: factor 11, fXIa: activated factor 11, fIX: factor 9, fIXa: activated factor 9, fX: factor 10, fXa: activated factor 10, fVII: factor 7, fVIIa: activated factor 7, fV: factor ... activation of Factor XII Factor XII is a coagulation factor found in the circulatory system It binds to foreign surfaces, and subsequently autocatalyses into an active form, via the cleavage of its ... requires a closer examination of the model tissue system to be studied 1.2 Vascular Tissue Engineering Vascular tissue engineering presents an attractive model for LBL tissue engineering for several...
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In vitro and in vivo assessments of PCL TCP composites for bone tissue engineering
... oLimitations to current bone grafts as discussed propel researchers to look into the field of bone tissue engineering for an ideal bone substitute 1.1.3 Strategies in BTE Tissue engineering is the restoration, ... trauma-related injuries or bone fractures Currently, the gold standard for bone grafts is autologous bone commonly taken from iliac crest Autologous bone are bones extracted from another part of patient’s ... In order to regenerate bone using BTE techniques, the understanding of the structure and cells which participate in bone repair is of utmost importance Bone is composed of around 70-90% of minerals...
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In vitro and in vivo evaluation of customized polycaprolactone tricalcium phosphate scaffolds for bone tissue engineering
... found to offer the advantage of a reduced frequency of soft tissue dehiscence in comparison to PCL-TCP sheets More improvements are needed to increase the efficiency of the PCL-TCP scaffolds in bone ... degree of Master of Engineering in the Department of Mechanical Engineering at the National University of Singapore under the supervision of Professor Teoh Swee Hin and Dr Alvin Yeo No part of this ... values of bone volume fraction detected after months of implantation of autografts and PCL-TCP scaffolds 100 Figure 5.15 The ratio of bone volume fraction for PCL-TCP scaffolds with respect to autografts...
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CGrand Challenges: A Strategic Plan for Bridge Engineering
... Outcome: Strategies to extend the service life of existing inventory of bridges and highway structures Practical Importance A significant portion of the nation’s inventory of 590,000 bridges is ... Identification of most useful data and information to be collected Identification of the types of structures/parts of structures where enhanced monitoring is needed and most promising Deployment of the ... demonstrations Development of recommended revisions to the AASHTO condition evaluation manuals Evaluation of current visual methods and recommendation of improvements Development of automated data collection...
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